Activation of human factor VII in the initiation of tissue factor- dependent coagulation
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چکیده
منابع مشابه
Activation of human factor VII in the initiation of tissue factor-dependent coagulation.
We have used activation peptide release assays to compare factor VII and activated factor VII (VIIa) activation of factor X, normal factor IX (IXN), and a variant factor IX (IXBmLE), which, after activation, is unable to back-activate factor VII. In purified systems, factor VII and VIIa each rapidly activated factor X, but after a one minute lag for factor VII. VIIa also readily activated both ...
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We recently showed that single-chain zymogen factor VII is converted to two-chain factor VIIa in an autocatalytic manner following complex formation with either cell-surface or solution-phase relipidated tissue factor apoprotein (Nakagaki, T., Foster, D. C., Berkner, K. L., and Kisiel, W. (1991) Biochemistry 30, 10819-10824). We have now performed a detailed kinetic analysis of the autoactivati...
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ژورنال
عنوان ژورنال: Blood
سال: 1986
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v68.3.685.685